Coconut Water Induces Clinical Remission in Mild to Moderate Ulcerative Colitis: Double-blind Placebo-controlled Trial

This study evaluated the efficacy and safety of coconut water as an adjunct to standard medical therapy in patients with mild to moderate ulcerative colitis. It was a single-center, double-blind, placebo-controlled trial. Of 121 patients screened, 95 were included in the modified intention-to-treat analysis (coconut water, n = 49; placebo, n = 46). Eligible participants had mild to moderate endoscopically active ulcerative colitis. Participants received either 400 mL/day of coconut water plus standard medical therapy or placebo plus standard medical therapy for 8 weeks. The primary outcome was clinical remission, while secondary outcomes included clinical response and adverse events at 8 weeks. The study concluded that coconut water was more effective than placebo for inducing clinical remission in patients with mild to moderate ulcerative colitis.