Faecal microbiota transplantation with anti- inflammatory diet (FMT- AID) followed by anti- inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial

This open-label randomized controlled trial evaluated the efficacy of multidonor faecal microbiota transplantation (FMT) combined with an anti-inflammatory diet (AID) in inducing remission and maintaining long-term remission among patients with mild to moderate ulcerative colitis. A total of 66 patients with active disease were included in the modified intention-to-treat analysis and were randomized to receive either FMT with an anti-inflammatory diet (n=35) or optimized standard medical therapy (n=31). The primary outcomes were clinical response and deep remission at 8 weeks, and deep remission and steroid-free clinical remission at 48 weeks. The study found that multidonor FMT with anti- inflammatory diet effectively induced deep remission in mild- moderate UC which was sustained with anti- inflammatory diet over 1 year.